What is nuclear factor kB?

What is nuclear factor kB?

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.

How does NF-kB enter the nucleus?

Activation of NF-κB requires the degradation of the IκBs, allowing free NF-κB complexes to translocate to the nucleus. However, transcription of the NFKBIA gene that encodes IκBα is induced immediately after NF-κB enters the nucleus and binds to its promoter.

Is NF KB a transcription factor?

Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that is involved in inflammatory and immune responses, as well as in regulation of expression of many other genes related to cell survival, proliferation, and differentiation.

Why is NF KB important?

A well-recognized function of NF-κB is regulation of inflammatory responses. In addition to mediating induction of various pro-inflammatory genes in innate immune cells, NF-κB regulates the activation, differentiation and effector function of inflammatory T cells.

Is NF-kB a transcription factor?

Is NF kB a transcription factor?

Is NF kB proinflammatory?

The pro-inflammatory function of NF-κB has been extensively studied in macrophages, a large family of innate immune cells that reside in different tissues and function in the front line of an immune response against infections.

What does NF kB bind to?

Activated NF-kB (p65) translocates from the cytoplasm to the nucleus, where it physically binds to myocardin, preventing the formation of myocardin/SRF/CArG ternary complex, and thus inhibiting SRF-regulated gene expression. This repression ultimately results in increased cell proliferation.

Is STAT3 a transcription factor?

STAT3 belongs to the signal transducer and activator of transcription (STAT) family of signal responsive transcription factors which consists of seven members encoded by distinct genes.