science | February 22, 2026

What are the most painful vaccines?

What are the most painful vaccines?

Some people report significant pain from certain vaccines, like the ones that inoculate against HPV, hepatitis A and B and especially DTaP, which includes diphtheria, tetanus and pertussis vaccines. Research data backs up people’s responses, says Dr. Messonnier.

Why we should not rub after injection?

Generally, rubbing or massaging the injection site area should be avoided through the time the drug is expected to reach peak levels to avoid intended absorption patterns.

How do you get rid of vaccine pain?

5 Exercises to Reduce Arm Soreness After the COVID-19 Vaccination

  1. Lateral deltoid raises.
  2. Standing shoulder external rotation in 90 degrees abduction.
  3. Standing shoulder external rotation with the arm at side.
  4. Overhead press.
  5. Horizontal abduction with external rotation.

Why do tetanus shots hurt so much?

If you have received a tetanus shot and your arm is sore, you may be experiencing discomfort due to your body’s production of antibodies in response to the viruses in the vaccine. If the pain persists for more than a few days after your shot, you may need to consult with a medical professional.

Why is my arm sore after a flu shot?

Soreness in your arm after getting a flu vaccine typically lasts no longer than one or two days. The pain and inflammation is your body’s natural response to a foreign invader. It’s a sign that your immune system is making antibodies, which is what offers you the protection from getting the actual virus.

Can I put ice after injection?

Apply ice or a warm compress after the injection. If your arm is sore, ice can help reduce pain and swelling. Some people find heat soothes better because it relaxes the muscle. Either approach is okay.

How long does muscle soreness last after flu shot?

Swelling, redness and soreness are common after the flu shot and can last 24-48 hours. “If you always experience soreness or swelling after a flu vaccination, take an ibuprofen about 2 hours prior to vaccination,” suggests Dr. Mora.

How do you relieve pain from intramuscular injection?

Treatment for post-injection inflammation

  1. Cold packs. These help reduce swelling, itching, and pain.
  2. Over-the-counter pain medicines. These help reduce pain and inflammation.
  3. Prescription medicine. These treat infection.