What are the long term side effects of docetaxel?
What are the long term side effects of docetaxel?
The most common long-term side effects of docetaxel are two types of nerve damage called sensory and motor peripheral neuropathy. Although it is less common, patients have also reported hair loss that lasts for years and appears to be permanent. In extremely rare cases, patients have developed leukemia.
How effective is docetaxel for prostate cancer?
Docetaxel, when used with or without prednisone, was the first chemotherapy drug proven to help patients live longer with advanced prostate cancer. The average survival was improved by about 2.5 months when compared to mitoxantrone with or without prednisone.
How long does docetaxel work for prostate?
Patients who had received 10 or more cycles of docetaxel had the greatest median OS of 33.0 months, compared with those who received 8 to 10 cycles (26.9 months) or 5-7 cycles (22.8 months) when treatment groups were combined (P < . 001) (Figure 2).
How long can you stay on docetaxel?
What to Expect During Treatment. Health care providers administer Taxotere through an IV for one hour ever three weeks, according to the drug’s label. Depending on the type of cancer, this can continue for several cycles.
When do docetaxel side effects start?
Painful muscles and joints. Your muscles or joints may ache or become painful two to three days after you have your treatment. This usually wears off after a few days to a week but may last a bit longer for some people.
What is the success rate of docetaxel?
In noncomparative trials in patients with NSCLC, docetaxel 75 or 100 mg/m2 produced objective response rates of 20 to 38% and 14 to 25% as a first-line or second-line monotherapy, respectively. In Japan, docetaxel 60 mg/m2 produced objective response rates of 19 to 25% in previously untreated patients.
How bad is docetaxel?
Docetaxel may cause severe lack or loss of strength, which can last a few days up to several weeks. Tell your doctor if you unusual tiredness or weakness. This medicine contains alcohol and may cause some people to become drowsy, dizzy, or less alert than they are normally.
How long is docetaxel effective?
Docetaxel extended predicted survival by an average of 0.89 years for patients with metastatic disease and 0.78 years for patients without metastatic disease. Docetaxel also extended discounted QALYs by 0.51 years for patients with metastatic disease and by 0.39 years for patients without metastatic disease.
Does docetaxel shrink tumors?
Chemotherapy drugs, such as docetaxel, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors.
