science | February 14, 2026

What are the embryo grades?

What are the embryo grades?

Each embryo is given 2 letter grades along with a description of the level of expansion. The letter grades are a simple A, B, or C, with A being the best. The first letter grade corresponds to the ICM and the second to the trophectoderm. For example, an embryo may receive the grade “AB.”.

Is a 5AA embryo good?

Using this embryo grading method, an embryo graded 5AA would be the highest quality, while an embryo graded 1CC would be the lowest quality and less likely to develop.

What is considered a poor grade embryo?

Having more than 25% fragmentation is considered “poor”. Here’s what increasing amounts of fragmentation can look like in a cleavage stage embryo: Fragmentation, among other things, can dictate the cleavage stage embryo’s grade.

Is 4AA or 5AA better?

What is the ‘perfect’ blastocyst grading score? A morphologically “perfect” day 5 embryo transfer would be a 4AA; good expansion and excellent inner cell mass and trophectoderm. When a blastocyst scores 5AA on day five the blastocyst is starting to “hatch” with normal appearing inner cell mass and trophectoderm.

Is it better to transfer 1 or 2 embryos?

Research still shows that transferring one embryo per cycle is the safest option. Transferring two increases the chance of a multiple pregnancy and associated complications. (Not by a huge margin, but the risk is still significant.)

What is a Grade 2 embryo?

Grade 2 embryos will have a small degree of fragmentation and or unevenness, but are still considered high quality. These embryos very rarely implant after transfer and are not considered viable enough to freeze regardless of how many cells they contain.

Is a 9 cell embryo on day 3 good?

An embryo that’s dividing well should ideally have between 6 to 10 cells by day 3. Research shows that 8 is best. (Day 3 embryos that had 8 or more cells showed a significantly higher live birth rate).

Can a 5AA embryo be a girl?

Gender selection is nearly impossible at this stage then. I personally managed to get a girl (4AA) and a boy (5AA), so anything is possible! With all of this information, it’s not surprising that we all want an army of top quality embryos!

What is a good quality embryo?

An embryo that’s dividing well should ideally have between 6 to 10 cells by day 3. Research shows that 8 is best. (Day 3 embryos that had 8 or more cells showed a significantly higher live birth rate). However, not all good quality embryos follow the rules.

What grade are blastocysts?

The Gardner blastocyst grading system assigns 3 separate quality scores to each blastocyst embryo:

Expansion gradeBlastocyst development and stage status
3Full blastocyst, cavity completely filling the embryo
4Expanded blastocyst, cavity larger than the embryo, with thinning of the shell
5Hatching out of the shell

What is a perfect embryo?

In a ‘perfect’ embryo the cells will divide evenly, so that each cell appears to be identical in size and shape. It is thought that embryos with very even sized cells have the highest chance of successfully implanting in the uterus, so these embryos are given the highest grade.

Can 1 embryo turn into twins?

Multiple births can develop through in vitro fertilization when more than one embryo is put back into the mother’s womb. Identical twins can develop even when only one embryo is put back into the womb.